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St. Paul and St. John had begun the struggle against Gnosticism, which in their time was in its early stages. Even so, it was already showing its pernicious tendencies: promoting its seductive secret knowledge in the Christian communities, confusing simple believers, and spreading the first dangerous 'pluralism'within the unity of the faith. A real showdown only became possible when all the various systems of Gnosticism had been constructed. This took place towards the end of the second century.

Irenaeus of Lyons The Scandal of the Incarnation: Irenaeus Against the Heresies

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